Tracing the Origin and Evolution of the Fungal Mycophenolic Acid Biosynthesis Pathway.

ABSTRACT: Like bacteria and plants, fungi produce a remarkable diversity of small molecules with potent activities for human health known as natural products or secondary metabolites. One such example is mycophenolic acid, a powerful immunosuppressant drug that is administered daily to millions of transplant recipients worldwide. Production of mycophenolic acid is restricted to a very limited number of filamentous fungi, and little is known about its biosynthetic modalities. It is therefore a particular challenge to improve our knowledge of the biosynthesis of this valuable natural compound, as this would contribute to a better understanding of the specialized metabolism of fungi and could also lead to the identification of new fungal producers for the supply of immunosuppressants. Here, we were int

SUBMITTER: Bidon B 

PROVIDER: S-EPMC11934065 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature