A Comparative Assessment of Self-limiting Genetic Control Strategies for Population Suppression.

ABSTRACT: Genetic control strategies are promising solutions for control of pest populations and invasive species. Methods utilizing repeated releases of males such as sterile insect technique (SIT), release of insects carrying a dominant lethal (RIDL), self-limiting gene drives, and gene disruptors are highly controllable methods, ensuring biosafety. Although models of these strategies have been built, detailed comparisons are lacking, particularly for some of the newer strategies. Here, we conducted a thorough comparative assessment of self-limiting genetic control strategies by individual-based simulation models. Specifically, we find that repeated releases greatly enhance suppression power of weak and self-limiting gene drives, enabling population elimination with even low efficiency and high fi

SUBMITTER: Han Y 

PROVIDER: S-EPMC11934067 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature