Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis.

ABSTRACT:

Objective

To determine the effects of intensive blood pressure treatment on orthostatic hypertension.

Design

Systematic review and individual participant data meta-analysis.

Data sources

MEDLINE, Embase, and Cochrane CENTRAL databases through 13 November 2023.

Inclusion criteria

Population: ≥500 adults, age ≥18 years with hypertension or elevated blood pressure; intervention: randomized trials of more intensive antihypertensive drug treatment (lower blood pressure goal or active agent) with duration ≥6 months; control: less intensive antihypertensive drug treatment (higher blood pressure goal or placebo); outcome: measured standing blood pressure.

Main outcomes

Orthostatic hypertension, defined as an increase in systolic blood pressure ≥20 mm Hg or diast

SUBMITTER: Juraschek SP 

PROVIDER: S-EPMC11934097 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature