Novel zerumbone-secondary amide hybrids: ultrasonic synthesis, cytotoxic evaluation, molecular docking and <i>in silico</i> ADMET studies.

ABSTRACT: Zerumbone, along with its various derivatives and structurally related compounds, has attracted significant scientific interest due to its broad-spectrum pharmacological properties, particularly its anticancer potential. In this study, novel zerumbone-secondary amide hybrids were successfully designed and synthesized with high yields using both conventional and ultrasonic methods. Reactions performed under ultrasonic conditions required significantly shorter reaction times than those conducted without ultrasound while maintaining comparable product yields. The cytotoxicity of the synthesized derivatives was evaluated against four human cancer cell lines: hepatocellular carcinoma (HepG2), lung carcinoma (A549), acute leukemia (HL-60), and gastric carcinoma (AGS). Most derivatives exhibited

SUBMITTER: Chinh PT 

PROVIDER: S-EPMC11934104 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature