The complex interaction between oestrogen receptor genes, oestradiol, and perinatal mood.

ABSTRACT:

Introduction

Genetic variations in oestrogen receptor (ER) genes are associated with inter-individual differences in the sensitivity of ER-α, ER-β and G protein-coupled oestrogen receptor (GPER). These sensitivity differences may modulate susceptibility to mood changes during phases of endogenous oestrogen fluctuations, thereby explaining individual vulnerability. This study examined the association between ER gene variations, oestradiol and perinatal mood disturbances.

Methods

A total of 159 women were observed during the perinatal period, providing saliva samples for oestradiol assessment and completing self-report measures of depressive and anxiety symptoms at five time points. Polymorphisms in ER genes were determined from dried blood spots. The associations were analyse

SUBMITTER: Zorzini G 

PROVIDER: S-EPMC11934172 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature