Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD.

ABSTRACT:

Introduction

Elevated cardiovascular rate pressure product (RPP) has been shown to predict cardiovascular mortality and is associated with poor cognitive test performance among older adults. However, it is unclear how RPP is related to the cerebrospinal fluid (CSF) biomarkers of neurodegeneration and neuroinflammation.

Methods

RPP was cross-sectionally evaluated as a predictor of CSF biomarker levels in a cohort of 310 cognitively unimpaired late-middle-aged adults at risk for Alzheimer's disease. The primary outcomes were CSF levels of α-Synuclein, glial fibrillary acidic protein, neurofilament light (NfL), soluble triggering receptor expressed in myeloid cells 2, and total tau. Further analyses examined amyloid beta (Aβ)42/Aβ40, phosphorylated tau 181 (pTau181), and pTau18

SUBMITTER: Odo CC 

PROVIDER: S-EPMC11934293 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature