The role of l-serine and l-threonine in the energy metabolism and nutritional stress response of <i>Trypanosoma cruzi</i>.

ABSTRACT: l-Serine and l-threonine have versatile roles in metabolism. In addition to their use in protein synthesis, these amino acids participate in the biosynthesis pathways of other amino acids and even phospholipids. Furthermore, l-serine and l-threonine can be substrates for a serine/threonine dehydratase (Ser/ThrDH), resulting in pyruvate and 2-oxobutyrate, respectively, thus being amino acids with anaplerotic potential. Trypanosoma cruzi, the etiological agent of Chagas disease, uses amino acids in several biological processes: metacyclogenesis, infection, resistance to nutritional and oxidative stress, osmotic control, etc. This study investigated the import and metabolism of l-serine, l-threonine, and glycine in T. cruzi. Our results demonstrate that these amino acids are tra

SUBMITTER: Alencar MB 

PROVIDER: S-EPMC11934319 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature