Development and validation of a biological frailty score based on CRP, haemoglobin, albumin and vitamin D within an electronic health record database in France: a cross-sectional study.

ABSTRACT:

Objectives

To easily detect frailty in a timely fashion, enabling targeted interventions and appropriate monitoring, will be a major worldwide public health and economic challenge as the proportion of older people increases in the population. Based on a review and meta-analysis showing that C-reactive protein (CRP), haemoglobin, albumin and vitamin D are associated with frailty, we aimed to develop and validate a biological score using these biomarkers for the detection of frailty.

Design

We conducted a retrospective, cross-sectional, monocentric study using the electronic healthcare database of Lille University Hospital, France.

Participants

Inclusion criteria were patients aged 50 and over, being hospitalised at Lille University Hospital between 1 January 2008 and 3

SUBMITTER: Mailliez A 

PROVIDER: S-EPMC11934387 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature