Molecular epidemiological study of exosomes circZNF609, circPUM1, IGF2 with ischemic stroke.

ABSTRACT:

Background

Ischemic stroke (IS) is a common cardiovascular disease (CVD). Insulin-like growth factor 2 (IGF2), circZNF609, and circPUM1 are involved in metabolic regulation, vascular health, neuroprotection, and inflammation modulation and are relevant to IS mechanisms. This study investigated the effects of plasma exosomal expression of circZNF609, circPUM1, and IGF2 on IS.

Methods

The expression of circZNF609, circPUM1, and IGF2 mRNA in exosomes was detected in 145 patients with IS and 290 controls using real-time qPCR in a cross-sectional study. Q1-Q4 represents the quartile groups based on the target gene expression levels.

Results

There was no significant difference in the expression levels of circZNF609 and circPUM1 in the plasma exosomes between the IS and cont

SUBMITTER: Fei S 

PROVIDER: S-EPMC11934478 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature