Reduction of colitis in mice by chemically programmed supramolecular nanoassemblies of vitamin-lipid conjugates.

ABSTRACT: Inflammatory bowel disease (IBD) is a relapsing disorder characterized by uncontrolled chronic inflammation of the gastrointestinal tract, posing a significant therapeutic challenge owing to the limited efficacy and undesirable side effects of current therapeutic options. A key pathological hallmark of IBD is the excessive production of reactive oxygen species (ROS). Hence, therapeutic strategies aimed at reducing ROS levels are promising for relieving these inflammatory conditions. Vitamin C-a natural nutrient for the human body-is well known for its potent antioxidant effects. However, the clinical development of vitamin C as a therapeutic drug has been hindered by its poor stability, rapid metabolism, and inadequate tissue accumulation. Herein, we report that the bioavailability of vita

SUBMITTER: Xian S 

PROVIDER: S-EPMC11934663 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature