Genetic diversity and population structure of Plasmodium falciparum across areas of varied malaria transmission intensities in Uganda.

ABSTRACT:

Background

Malaria remains a significant global health threat, with sub-Saharan Africa (SSA) bearing the highest burden of the disease. Plasmodium falciparum is the predominant species in the region, leading to substantial morbidity and mortality. Despite intensified control efforts over the last two decades, P. falciparum genetic diversity and multiplicity of infections (MOI) continue to pose significant challenges to malaria elimination in the region. This study assessed P. falciparum genetic diversity and population structure in areas with low, medium, and high malaria transmission intensities in Uganda.

Methods

A total of 288 P. falciparum-positive samples from children (6 months to 10 years) and adults (≥ 18 years) living in Jinja (low transmission), Kanungu (medium tra

SUBMITTER: Mwesigwa A 

PROVIDER: S-EPMC11934718 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature