Exploring the impact of glycemic variability on clinical outcomes in critically ill cerebral infarction patients.

ABSTRACT:

Background

Glycemic variability (GV) is a key determinant of outcomes in critically ill patients, yet its impact on cerebral infarction patients in intensive care units (ICUs) remains underexplored. This study evaluates the association between GV and clinical outcomes, including discharge outcomes, 90-day and 1-year mortality, and ICU/hospital length of stay (LOS).

Methods

This retrospective study of 778 cerebral infarction patients from the MIMIC-IV database assessed GV, calculated as the glucose standard deviation-to-mean ratio during ICU stays. Regression models evaluated GV's impact on discharge outcomes, mortality, and ICU/hospital LOS, with adjustments for confounders. Restricted cubic spline analyses identified risk thresholds, while sensitivity and subgroup analyses

SUBMITTER: Yang H 

PROVIDER: S-EPMC11934728 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature