Dual-modality immune nano-activator harnessing Mn²⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy.

ABSTRACT: Manganese ions (Mn²⁺) have emerged as promising activators of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. However, their clinical application was hindered by low bioavailability and limited immune activation pathways, which impaired their ability to trigger robust immune responses and achieve significant antitumor effects. To address these challenges, we developed a dual-modality immune nano-activator by coordinating manganese ions with quercetin. This strategy was designed to enhance the cGAS-STING pathway activation and elicit the immunogenic cell death, thereby strengthening the antitumor immune response. The engineered nano-activator demonstrated superior tumor-targeting ability and efficient cellular internalization. Upon exposure to nea

SUBMITTER: Ma S 

PROVIDER: S-EPMC11934746 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature