Curcumin inhibits ferroptosis-mediated vascular occlusion by regulating the CXCL10/CXCR3 axis in retinopathy of prematurity.

ABSTRACT: Retinopathy of prematurity (ROP) is a disorder that causes blindness in children at a high incidence. Retinal endothelial cells are damaged by variations in oxygen partial pressure, which leads to vascular obstruction and, eventually, ischemia and hypoxia, which cause the formation of new blood vessels. However, little is known about the molecular mechanism of hyperoxic vascular occlusion. High oxygen levels are thought to cause ferroptosis. In this study, experiments with both animal and in vitro models demonstrated that elevated expression of C-X-C motif chemokine ligand 10 (CXCL10)/C-X-C motif chemokine receptor 3 (CXCR3) in retinal vascular endothelial cells induced ferroptosis. Curcumin decreased ferroptosis by inhibiting the production of CXCL10/CXCR3. Curcumin also preserved distal

SUBMITTER: Niu R 

PROVIDER: S-EPMC11934774 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature