An evolutionarily conserved constellation of functional cis-elements programs the virus-responsive fate of the human (epi)genome.

ABSTRACT: Human health depends on perplexing defensive cellular responses against microbial pathogens like Viruses. Despite the major effort undertaken, the (epi)genomic mechanisms that human cells utilize to tailor defensive gene expression programs against microbial attacks have remained inadequately understood, mainly due to a significant lack of recording of the in vivo functional cis-regulatory modules (CRMs) of the human genome. Here, we introduce the virus-responsive fate of the human (epi)genome as characterized in naïve and infected cells by functional genomics, computational biology, DNA evolution, and DNA Grammar and Syntax investigations. We discovered that multitudes of novel functional virus-responsive CRMs (vrCRMs) compose typical enhancers (tEs), super-enhancers (SEs), repetitive-DNA

SUBMITTER: Koutsi MA 

PROVIDER: S-EPMC11934927 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature