Structural Effect of Rhenium- and Iridium-Complex Liposome Composition on Their Selectivity for Antimicrobial Photodynamic Therapy.

ABSTRACT: Antimicrobial photodynamic therapy (aPDT) is an alternative to antibiotics that has potential for the treatment of chronic skin wounds, but requires improved, highly selective photosensitizer systems. Rhenium (Re)-complex- and iridium (Ir)-complex-based phospholipid conjugates, as PDT-functional building blocks for liposomes, are presented, and varying structural components and proportion of compounds are explored, including adjusting the cholesterol and polyethylene glycol (PEG)-lipid contents, incorporating ethylenediaminetetraacetic acid (EDTA)-lipid, and introducing the cationic lipid 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) to enhance their efficacy and selectivity in aPDT. Ir/Re-liposomes have nanostructurally enhanced photoactivity compared to monomeric Ir/Re-lipids. Ir-lipo

SUBMITTER: Kassab G 

PROVIDER: S-EPMC11934977 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature