Hierarchical Microcarriers Loaded with Peptide Dendrimer-Grafted Methotrexate for Rheumatoid Arthritis Treatment.

ABSTRACT: Rheumatoid arthritis (RA) is one of the leading causes of disability due to the autoimmune destruction of synovial joints. Great efforts have been put into developing multifunctional drug delivery systems for delaying the progression of RA. Herein, a novel locally injectable, hierarchically structured delivery system with a hyaluronic acid (HA) microparticle and an MTX-conjugated nanoparticle for promoted RA treatment is proposed. In this system, MTX is chemically grafted onto a peptide dendrimer-based nanoparticle (G-MTX). These nanoparticles are encapsulated inside HA microparticles (H-G-MTX) using microfluidics to realize the system. The G-MTX can be released from the degradable HA microparticles in the acidic environment of inflamed RA joints. As the G-MTX shows an enhanced intracellul

SUBMITTER: Li Y 

PROVIDER: S-EPMC11935003 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature