Biomimetic Functional Nanocomplexes for Photothermal Cancer Chemoimmunotheranostics.

ABSTRACT: This study presents a novel multimodal cancer theranostic platform developed using tumor cell-coated biomimetic carbon nanohorn (CNH) complexes that encapsulate the anticancer drug paclitaxel (PTX). This platform combines photothermal therapy, chemotherapy, and immunotherapy to fight against malignant colorectal cancer. These engineered nanocomplexes are designed to deliver sufficient PTX molecules into a targeted solid tumor in a light-controllable manner while inducing significant photothermal and antitumor immune responses. The outstanding photothermal conversion property of the CNHs under near-infrared light enables effective cancer cell ablation and awakening of cytotoxic immune responses. Tumor cell membrane-coated CNHs show improved water dispersibility, immune evasion, and targetin

SUBMITTER: Sang N 

PROVIDER: S-EPMC11935030 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature