Tuning the Immune Cell Response through Surface Nanotopography Engineering.

ABSTRACT: Dendritic cells (DCs) are central regulators of the immune response by detecting inflammatory signals, aberrant cells, or pathogens. DC-mediated immune surveillance requires morphology changes to adapt to the physical and biochemical cues of the external environment. These changes are assisted by a dynamic actin cytoskeleton-membrane interface connected to surface receptors that will trigger signaling cascades. In recent years, the development of synthetic immune environments has allowed to investigate the impact of the external environment in the immune cell response. In this direction, the bioengineering of functional topographical features should make it possible to establish how membrane morphology modulates specific cellular functions in DCs. Herein, the engineering of one-dimensional

SUBMITTER: Rathar R 

PROVIDER: S-EPMC11935051 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature