Vanadium Carbide Quantum Dots Exert Efficient Anti-Inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia and Mice.

ABSTRACT: The regulation of glial cell activation is a critical step for the treatment or prevention of neuroinflammation-based brain diseases. However, the development of therapeutic drugs that pass the blood-brain barrier (BBB) and inhibit the glia cell activation remains a significant challenge. Herein, an ultrasmall 2D vanadium carbide quantum dots (V₂C QDs) that are capable of crossing the BBB are prepared, and the admirable anti-neuroinflammatory effects are presented. The prepared 2D V₂C QDs with an average size of 2.54 nm show good hydrophilicity, physiological stability, and effective BBB-crossing ability. The biological effect of V₂C QDs on inflammatory reactions demonstrates fascinating results in preventing the impairment of learning and memory in BALB/c

SUBMITTER: He Z 

PROVIDER: S-EPMC11935053 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature