T cell immune senescence is associated with frailty and sarcopenia in lung transplant candidates.

ABSTRACT:

Backgound

Older lung transplant recipients experience increased rates of adverse clinical outcomes, including infection compared with younger patients, potentially related to impaired cell-mediated immunity, frailty, and sarcopenia.

Methods

Patients over age 55 years undergoing evaluation for lung transplantation were evaluated for sarcopenia by cross-sectional area and average attenuation of the pectoralis major muscle on chest computed tomography. Frailty was measured using the Fried Frailty Phenotype. Immune phenotyping was performed using multichannel flow cytometry of peripheral blood mononuclear cells (PBMC) in a total of 26 lung transplant candidates.

Results

The median patient age was 65, primarily with restrictive lung disease (76.9%). Hospital readmission wa

SUBMITTER: Schaenman JM 

PROVIDER: S-EPMC11935382 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature