Impact of normothermic regional perfusion during DCD recovery on lung allograft function: A preclinical study.

ABSTRACT:

Background

Normothermic regional perfusion (NRP) has been growing as a novel procurement strategy after circulatory death (donation after circulatory death (DCD)) in the context of heart transplantation. However, the impact of NRP on lung graft viability is largely unknown. We sought to determine lung function after thoraco-abdominal NRP (TA-NRP) in a clinically relevant porcine DCD model.

Methods

Donor domestic pigs underwent hypoxic cardiac arrest to simulate DCD procurement and were randomly allocated to either 1-hour resuscitation on TA-NRP (n = 4) or direct lung procurement (direct procurement and perfusion (DPP), n = 4). All lungs were placed on ex-vivo lung perfusion (EVLP) and evaluated for 3 hours to assess functional outcome parameters and suitability

SUBMITTER: Ribeiro RVP 

PROVIDER: S-EPMC11935417 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature