Evaluation of target temperature on effectiveness of myocardial preservation during hypothermic machine perfusion.

ABSTRACT:

Background

Ex-situ heart perfusion (ESHP) has been proposed as an optimal method for preserving donated hearts prior to transplantation. Hypothermic oxygenated perfusion (HOP) is a simple method from a device design perspective, with enhanced safety compared to normothermic perfusion in the event of device failure. However, the optimal temperature for cardiac HOP has yet to be determined. We evaluated the effectiveness of 12-hour HOP using University of Wisconsin Machine Perfusion Solution (UWMPS) in different temperatures compared to static cold storage (SCS) for 6 hours followed by simulated transplantation. Additionally, we sought to determine the impact of oxygen supplementation in hypothermic ESHP in the heart function preservation.

Methods

Hearts were procured from Yor

SUBMITTER: da Silva GMA 

PROVIDER: S-EPMC11935436 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature