Differential effects of donor factors on post-transplant survival in lung transplantation.

ABSTRACT:

Background

Predicting post-transplant (PT) survival in lung allocation remains an elusive goal. We analyzed the impact of donor factors on PT survival and how these relationships vary among transplant recipients.

Methods

We studied primary bilateral lung transplant recipients (n = 7,609) from the US Scientific Registry of Transplant Recipients (19 February 2015-1 February 2020). Main and interaction effects were evaluated and adjusted across candidate age, sex, and diagnosis. Models predicting PT survival were compared to the PT Composite Allocation Score model (PT-CAS): (1) Cox regression donor multivariable model (COX), (2) COX + PT-CAS, (3) random forest model (RF), and (4) RF + PT-CAS. Model discrimination and calibration measures were compared.

Results

Int

SUBMITTER: Lehr CJ 

PROVIDER: S-EPMC11935449 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature