Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model.

ABSTRACT:

Background

It is unknown whether ligation of supra-aortic vessels during thoraco-abdominal normothermic regional perfusion (TA-NRP) can prevent postmortem brain function, ensuring the permanence of death. Our objective was to determine if ligation of the supra-aortic vessels during TA-NRP prevents resumption of intracranial blood flow, brain electrical activity and clinical brain function in a porcine model of organ donation after circulatory arrest.

Methods

Neuromonitoring was performed in 9 porcine experiments, in which supra-aortic vessels were ligated.

Results

During TA-NRP and organ procurement, no motor reaction to pain, spontaneous ventilation, eye movement or change in pupillary function were observed. Angiography demonstrated absence of supra-aortic blood flo

SUBMITTER: Glorion M 

PROVIDER: S-EPMC11935451 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature