Direct oral anticoagulants versus warfarin in adult heart transplant recipients.

ABSTRACT:

Background

Direct oral anticoagulants (DOACs) have transformed the field of anticoagulation, offering more predictable pharmacokinetic and pharmacodynamic characteristics when compared to traditional warfarin therapy. DOAC use in the heart transplant population is particularly important to further study due to the high risk of venothromboembolism and the potential for significant drug interactions and altered pharmacokinetics post-transplantation.

Methods

A single center, retrospective cohort study was performed in adult heart transplant recipients requiring anticoagulation following transplantation between January 2010 and July 2021. Primary outcomes included incidence of bleeding and breakthrough thromboembolic events.

Results

Ninety-five patients met inclusion crit

SUBMITTER: Shitanishi L 

PROVIDER: S-EPMC11935520 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature