Assessment of Inflammatory Biomarkers and Incident Atrial Fibrillation in Older Adults.

ABSTRACT:

Background

Available evidence supports the importance of inflammation in atrial fibrillation (AF) pathogenesis, yet general anti-inflammatory therapies have failed to show benefit for prevention of the arrhythmia. Better understanding of the specific inflammatory pathways involved is necessary to advance therapeutics.

Methods and results

We evaluated 9 circulating markers of inflammation measured by immunoassays and incidence of AF in a population-based older cohort. Biomarkers included measures of general inflammation and the NLR (nucleotide-binding oligomerization domain-like receptor) family pyrin domain containing 3 inflammasome, TNF-α (tumor necrosis factor α), monocyte activation markers, and sIL-2 (soluble interleukin-2). Among 5726 participants (median age 72 years),

SUBMITTER: Shitole SG 

PROVIDER: S-EPMC11935547 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature