α1_C S1928 Phosphorylation of Ca_V1.2 Channel Controls Vascular Reactivity and Blood Pressure.

ABSTRACT:

Background

Increased vascular Ca_V1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are unclear. We hypothesize that α1_C phosphorylation at serine 1928 (S1928) is a key event mediating increased Ca_V1.2 channel function and vascular reactivity during angiotensin II signaling and hypertension.

Methods and results

The hypothesis was examined in freshly isolated mesenteric arteries and arterial myocytes from control and angiotensin II-infused mice. Specific techniques include superresolution imaging, proximity ligation assay, patch-clamp electrophysiology, Ca²⁺ imaging, pressure myography, laser

SUBMITTER: Flores-Tamez VA 

PROVIDER: S-EPMC11935578 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature