Short Sleep Duration and Hypertension: A Double Hit for the Brain.

ABSTRACT:

Background

Short sleep duration has been associated with an increased risk of cognitive impairment and dementia. Short sleep is associated with elevated blood pressure, yet the combined insult of short sleep and hypertension on brain health remains unclear. We assessed whether the association of sleep duration with cognition and vascular brain injury was moderated by hypertensive status.

Methods and results

A total of 682 dementia-free participants (mean age, 62±9 years; 53% women) from the Framingham Heart Study completed assessments of cognition, office blood pressure, and self-reported habitual and polysomnography-derived sleep duration; 637 underwent brain magnetic resonance imaging. Linear regressions were performed to assess effect modification by hypertensive status o

SUBMITTER: Yiallourou S 

PROVIDER: S-EPMC11935671 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature