Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study.

ABSTRACT:

Background

This study aimed to examine whether baseline atherosclerosis was associated with subsequent short-term domain-specific cognitive decline.

Methods and results

This research was based on the BRAVE (Beijing Research on Aging and Vessel) study, a population-based prospective cohort study of adults aged 40 to 80 years, free of dementia. At baseline (wave 1, 2019), cognitive assessments and atherosclerosis measures, including carotid intima-media thickness, carotid plaques, coronary artery calcification, and brachial-ankle pulse wave velocity were conducted. Cognitive function was reassessed in wave 2 (2022-2023) using linear mixed models for analysis. A total of 932 participants (63.7% women; mean age, 60.0±6.9 years) were included. Compared with the lowest tertile of

SUBMITTER: Liang J 

PROVIDER: S-EPMC11935699 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature