Tracking of Vascular Measures From Infancy to Early Childhood: A Cohort Study.

ABSTRACT:

Background

Atherosclerosis develops across the life course, and variation in aortic intima-media thickness (IMT) is evident from infancy onward, although most early-life data are cross-sectional. We investigated whether abdominal aortic IMT at age 6 weeks is associated with vascular measures at 4 years and the relationship of prenatal and perinatal exposures with these measures in early childhood.

Methods and results

We analyzed data from 518 participants with 6-week and 4-year vascular measures from the Barwon Infant Study. Aortic IMT was measured at 6 weeks (mean, 6.1±SD 1.5 weeks) and aortic and carotid IMT, carotid-femoral pulse wave velocity, and blood pressure at 4 years of age (4.3±0.3 years). Associations of early-life exposures-maternal enteric microbiome, smoking a

SUBMITTER: Mansell T 

PROVIDER: S-EPMC11935727 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature