Efficient Isolation and In Situ Identification of Viable Circulating Tumor Cells Using Dual-Responsive Fluorescent-Magnetic Nanoparticles.

ABSTRACT: Detecting circulating tumor cells (CTCs) from the peripheral blood of cancer patients is a promising approach for diagnosing early-stage cancers, monitoring disease progression, and prescribing personalized anticancer therapy. However, it is still challenging to achieve effective and cell-friendly isolation of CTCs due to their scarcity, heterogeneity, and vulnerability. Herein, a novel multifunctional platform based on fluorescent-magnetic Fe₃O₄/Rhm B@ZIF-8-pTA nanoparticles (FR@Z-pTA NPs) is developed for efficient CTCs isolation. FR@Z-pTA NPs not only capture more than 88% of rare cancer cells for both EpCAM-positive cells (MCF-7, HepG2) and EpCAM-negative cells (MDA-MB-231, HeLa) but also effectively release the captured cells with high efficiency (>80%) and viabi

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11936015 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature