Microneedle-Integrated Device for Transdermal Sampling and Analyses of Targeted Biomarkers.

ABSTRACT: Currently available point-of-care systems for body fluid collection exhibit poor integration with sensors. Herein, the design of a disposable device for interstitial fluid (ISF) extraction as well as glucose, lactate, and potassium ion (K⁺) monitoring is reported on. It is minimally invasive and appropriate for single use, minimizing the risk of infection to the user. This microscale device contains a 3D-printed cap-like structure with a four-by-four microneedle (MN) array, bioreceptor-modified carbon fiber (CF)-sensing surface, and negative pressure convection technology. These features are incorporated within a compact, self-contained, and manually operated microscale device, which is capable of withdrawing ≈3.0 μL of ISF from the skin. MN arrays applied with an upward driving

SUBMITTER: Shukla S 

PROVIDER: S-EPMC11936029 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature