Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors.

ABSTRACT: Major guidelines for living-donor kidney transplantation underscore the need for pre-donation evaluation of renal function, hypertension, obesity, diabetes mellitus, and albuminuria to minimize the risk of donation from marginal donors. However, validity is yet to be established. We retrospectively investigated the relationship between clinical characteristics and histological indices in baseline renal biopsies (0-h biopsies) and whether these parameters could predict renal function in living kidney donors one year post-donation. Seventy-six living kidney donors were recruited for this study. In histological analyses, glomerulosclerosis, arteriosclerosis, arteriolosclerosis, arteriolar hyalinosis, and interstitial fibrosis and tubular atrophy scores/indices were evaluated. Post-donation se

SUBMITTER: Kano Y 

PROVIDER: S-EPMC11936170 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature