Proteomic characterization of clinical Candida glabrata isolates with varying degrees of virulence and resistance to fluconazole.

ABSTRACT: Candida glabrata, an opportunistic fungal pathogen, is a significant contributor to mortality among individuals with weakened immune systems. Antifungal drugs such as azoles work by inhibiting the Erg11 enzyme, altering the conversion of lanosterol to ergosterol. Resistance to azoles is increasing among Candida species worldwide, and in Lebanon. This study aims to determine the identity of cell wall proteins that could be involved in resistance and virulence in Candida glabrata Lebanese hospital isolates. Four isolates with varying degrees of resistance and virulence to fluconazole were subjected to proteomic analysis. Cell wall proteins of each isolate were extracted and analyzed using MALDI TOF TOF mass spectrometry to identify proteins responsible for virulence and resistance under expo

SUBMITTER: El Khoury P 

PROVIDER: S-EPMC11936215 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature