Time-restricted eating in early-stage Huntington's disease: A 12-week interventional clinical trial protocol.

ABSTRACT: Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by a variety of debilitating symptoms including abnormal motor control, cognitive impairment, and psychiatric disturbances. Despite significant efforts, efficacious treatments to alter the course of HD remain elusive, highlighting the need to explore new therapeutic strategies, including lifestyle changes that may delay the onset of symptoms and slow disease progression. Recent research indicates that time-restricted eating (TRE), a type of intermittent fasting where caloric intake is confined to a specific time window each day, may be beneficial in treating neurodegenerative diseases like HD. TRE has been found to enhance mitochondrial function, stimulate autophagy, lower oxidative stress, and improve cogn

SUBMITTER: Wells RG 

PROVIDER: S-EPMC11936236 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature