Oncosis is the predominant type of cell death in rhabdomyolysis following exertional heat stroke.

ABSTRACT:

Background

Rhabdomyolysis (RM), particularly heat exhaustion-associated rhabdomyolysis (ehsRM), is a significant clinical issue associated with high mortality and healthcare costs. However, the cellular death mechanisms remain incompletely understood. Oncosis, a form of passive cell death distinct from apoptosis, is characterized by cell swelling and triggered by ATP depletion. Additionally, porimin, a specific biomarker, can uniquely identify oncosis. This study aims to investigate the role and mechanisms of oncosis in both in vitro and in vivo models of ehsRM.

Objective

This study aims to investigate the role and mechanisms of oncosis in both in vitro and in vivo models of ehsRM.

Methods

In the in vitro study, 6-8-week-old male rats were subjected to treadmill exerc

SUBMITTER: Li C 

PROVIDER: S-EPMC11936275 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature