Incidence and Genetic Risk of Juvenile Idiopathic Arthritis in Norway by Latitude.

ABSTRACT:

Objective

We aimed to investigate the incidence of juvenile idiopathic arthritis (JIA) in the three geographic regions of Norway and whether potential regional incidence differences are explained by environmental or genetic factors across regions.

Methods

We conducted a register-based cohort study including all Norwegian children born from 2004 to 2019, with follow-up throughout 2020. The JIA diagnosis, defined by at least two International Classification of Diseases, Tenth Revision codes for JIA, was validated against medical records. The incidence rate (IR) and hazard ratio (HR) for JIA were estimated for all Norway and for the North, Mid, and South regions. In a subsample from the Norwegian Mother, Father, and Child Cohort Study (MoBa), the genetic risk for JIA was assess

SUBMITTER: Hestetun SV 

PROVIDER: S-EPMC11936499 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature