Acetaminophen and Clinical Outcomes in Sepsis: A Retrospective Propensity Score Analysis of the Ibuprofen in Sepsis Study.

ABSTRACT:

Background

The Ibuprofen in Sepsis Study (ISS) randomized trial found no difference in duration of shock, ARDS, or mortality with ibuprofen treatment for sepsis. However, higher use of acetaminophen, a known hemoprotein reductant with potentially beneficial effects in sepsis, as an antipyretic in the control arm may have masked the clinical benefits from either drug.

Research question

Does an association exist between administration of acetaminophen and clinical outcomes in adults with sepsis?

Study design and methods

We performed a retrospective propensity-matched analysis of the previously reported ISS trial. We created a propensity score for receiving acetaminophen during the first 2 study days using sex, age, presence of shock at enrollment, trial study drug assig

SUBMITTER: Obeidalla SN 

PROVIDER: S-EPMC11936508 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature