The Ocular Manifestations of Individuals With Down Syndrome: A Systematic Review and Meta-Analysis.

ABSTRACT: Background: Down syndrome (DS) is the most common genetic cause of intellectual disability. Ocular manifestations occur frequently in people with DS (pwDS) but to date, there is no systematic review or meta-analysis of these conditions across the lifespan. Methods: PubMed, Medline, Embase, Web of Science and Scopus were searched for observational studies reporting ocular manifestations in pwDS, without limiting publication date. The proportion of pwDS with specific ocular manifestations were meta-analysed to obtain a pooled incidence using a random effects model. Sources of heterogeneity were assessed using a meta-regression analysis. For manifestations reported, but without sufficient prevalence data available, a narrative approach was adopted. Results: The search ide

SUBMITTER: Beresford-Webb JA 

PROVIDER: S-EPMC11936530 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature