Mechanistic insights into Guizhi Fuzi decoction for lumbar disc herniation: Integrating network pharmacology and bioinformatics approach.

ABSTRACT: The ancient Chinese medical texts have recorded Guizhi Fuzi decoction (GZFZT) as a therapeutic intervention for lumbar disc herniation (LDH), and its clinical efficacy has been validated in medical practice. This research endeavor is specifically designed to delve into and elucidate its precise underlying mechanisms of action, leveraging the sophisticated methodologies of network pharmacology and bioinformatics. In this study, we used the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform to extract active compounds and targets from the traditional Chinese medicine GZFZT. Subsequently, we integrated LDH disease target information from DisGeNET, GeneCards, OMIM, and GEO database. By combining this with drug-effective targets, we screened for common targets. Bas

SUBMITTER: Peng J 

PROVIDER: S-EPMC11936605 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature