Structure modification of luteolin and the influence of its derivatives on biological activities.

ABSTRACT:

Introduction

This research aims to synthesize luteolin derivatives from hemp seeds by means of chemical synthesis, improve the synthesis process, simplify the procedure, and increase the yield to obtain new luteolin derivatives. Additionally, anti-inflammatory and antioxidant activities of hemp seed extracts and newly synthesized substances are tested to screen out substances with high anti-inflammatory and antioxidant activities.

Methods

Using luteolin as the raw material, acetyl, propionyl, and butyryl groups are introduced into the molecular structure of luteolin. A one-pot synthesis method is employed to modify the hydroxyl groups at positions 5, 7, 3', and 4' to obtain six new luteolin acyl derivatives. The molar ratio of reaction conditions is 1:4. Pyridine (20 mL) is

SUBMITTER: Kong L 

PROVIDER: S-EPMC11936824 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature