Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality.

ABSTRACT: The biology underlying the connection between social relationships and health is largely unknown. Here, leveraging data from 42,062 participants across 2,920 plasma proteins in the UK Biobank, we characterized the proteomic signatures of social isolation and loneliness through proteome-wide association study and protein co-expression network analysis. Proteins linked to these constructs were implicated in inflammation, antiviral responses and complement systems. More than half of these proteins were prospectively linked to cardiovascular disease, type 2 diabetes, stroke and mortality during a 14 year follow-up. Moreover, Mendelian randomization (MR) analysis suggested causal relationships from loneliness to five proteins, with two proteins (ADM and ASGR1) further supported by colocalizatio

SUBMITTER: Shen C 

PROVIDER: S-EPMC11936835 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature