Jingtian granule alleviates adenine-induced renal fibrosis in mice through SIRT3-Mediated deacetylation of P53.

ABSTRACT:

Background

Renal fibrosis is a hallmark and the final outcome of chronic kidney disease (CKD). Jingtian Granule (JT), a traditional formula used in the clinical treatment of CKD for many years. However, the mechanism of action of JT against renal interstitial fibrosis remain unknown.

Objective

This study aimed to explore the potential effects and mechanisms of JT on adenine - diet - induced CKD in mice.

Methods

Renal interstitial fibrosis was induced in mice by adenine - diet and treated with JT. Renal function was assessed by measuring blood urea nitrogen and serum creatinine levels. Masson's staining and type I collagen expression were used to evaluate renal collagen deposition. RNA sequencing was used to analyze the expression levels of mRNA in mouse kidney samples

SUBMITTER: Xiong Z 

PROVIDER: S-EPMC11936886 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature