Variable cerebral blood flow responsiveness to acute hypoxic hypoxia.

ABSTRACT:

Introduction

Cerebrovascular reactivity (CVR) to changes in blood carbon dioxide and oxygen levels is a robust indicator of vascular health. Although CVR is typically assessed with hypercapnia, the interplay between carbon dioxide and oxygen, and their ultimate roles in dictating vascular tone, can vary with pathology. Methods to characterize vasoreactivity to oxygen changes, particularly hypoxia, would provide important complementary information to established hypercapnia techniques. However, existing methods to study hypoxic CVR, typically with arterial spin labeling (ASL) MRI, demonstrate high variability and paradoxical responses.

Methods

To understand whether these responses are real or due to methodological confounds of ASL, we used phase-contrast MRI to quantify whole

SUBMITTER: Johnson HR 

PROVIDER: S-EPMC11936916 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature