The role of intestinal homeostasis in sevoflurane-induced myelin development and cognitive impairment in neonatal mice.

ABSTRACT:

Background

Inhalational anesthetic sevoflurane is commonly used in pediatric anesthesia. Multiple exposures to sevoflurane in early postnatal life have been associated with long-term abnormalities in myelin development and cognitive and memory impairments, although the underlying mechanisms remain incompletely elucidated. Disruption of gut microbiota is recognized as an important contributor to neurological diseases. Here, we explore the potential mechanisms underlying the abnormal myelin development induced by multiple sevoflurane exposures in neonatal rats by analyzing gut homeostasis.

Methods

Six-day-old (P6) C57BL/6 mice were exposed to 3% sevoflurane for 2 hours per day for three consecutive days. Mice exposed to a mixture of 60% nitrogen and oxygen under the same condi

SUBMITTER: Liu C 

PROVIDER: S-EPMC11936920 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature