Consumption of dopamine receptor 1 agonist SKF-38393 reduces constant-light-induced hyperactivity, depression-like, and anxiety-like behaviors in a sex specific manner in C57BL/6J mice.

ABSTRACT: Artificial light exposure during nighttime, including constant light (LL), is an increasingly prevalent environmental occurrence linked to impaired mood and cognitive impairments in both humans and animal models. Dopamine and dopamine 1 receptors are well known to modulate circadian rhythms and mood. This study investigated the effects of LL on anxiety-like, depressive-like, and cognitive behaviors in male and female C57BL/6J mice and assessed whether consumption of SKF-38393, a dopamine 1 receptor agonist, can mitigate these negative behavioral outcomes. Mice were exposed to LL or a standard 12:12 light:dark cycle (LD) for 6 weeks, with subgroups receiving either SKF-38393 or water. All mice had their circadian rhythms continuously monitored and were placed within behavioral tests that as

SUBMITTER: Guindon GE 

PROVIDER: S-EPMC11936926 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature