Mechanistic investigation of Shuanghuanglian against infectious bronchitis in chickens: a network pharmacology and molecular dynamics study.

ABSTRACT:

Introduction

Infectious bronchitis (IB) poses a major challenge to global poultry production, causing substantial economic burdens and underscoring the necessity for novel therapeutic interventions given the limitations of current vaccines and conventional antiviral agents. The purpose of this study is to comprehensively explore the active components in Shuanghuanglian and their interaction with the key pathological targets of IBV (Infectious bronchitis virus) infection. By using advanced computational methods, this study aims not only to identify the therapeutic potential of active ingredients, but also to reveal their mechanism of action against IBV.

Methods

Through integrative systems pharmacology approaches, we systematically investigated Shuanghuanglian and its phytoche

SUBMITTER: You F 

PROVIDER: S-EPMC11936991 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature