Pulmonary lymphoid tissue induced after SARS-CoV-2 infection in rhesus macaques.

ABSTRACT:

Introduction

Lung diseases are widespread worldwide. Pulmonary immunity plays a vital role against lung pathogens, including SARS-CoV-2 infection. Understanding the pathogenesis, including the development of local immune responses to infection, is fundamental for developing interventions to control the viral infection.

Methods

Using immunohistochemistry, we investigated the distribution of immune cells in the lungs of rhesus macaques experimentally infected with SARS-CoV-2 and euthanized 11-14 days later.

Results

Tertiary lymphoid tissue was found in all SARS-CoV-2 infected animals. The number (13.9 vs 1.5 iPLT number/ lung cm²), size (25992 vs 13946 µm²) and total area (0.46 vs 0.02 mm² iPLT/ lung cm²) of the lymphoid tissu

SUBMITTER: Ma ZM 

PROVIDER: S-EPMC11937022 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature