Distinct brain activity patterns associated with traditional Chinese medicine syndromes: a task-fMRI study of mild cognitive impairment.

ABSTRACT:

Background

Abnormalities in brain activity patterns during episodic memory tasks have been inconsistently reported in amnestic mild cognitive impairment (aMCI) patients using functional magnetic resonance imaging (fMRI). This study applied traditional Chinese medicine (TCM) syndrome differentiation to categorize aMCI patients into distinct subgroups, aiming to clarify the neural mechanisms underlying their cognitive profiles.

Methods

Participants included aMCI patients categorized into the turbid phlegm clouding the orifices (PCO) or spleen-kidney deficiency (SKD) syndrome subgroups, alongside cognitively normal controls (NC) matched for age and gender. Neuropsychological assessments were performed, and fMRI scans were acquired during an episodic memory task involving the re

SUBMITTER: Li Z 

PROVIDER: S-EPMC11937078 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature